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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 8(64), 2020

DOI: 10.1128/aac.00788-20

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Sequential Time-Kill, a Simple Experimental Trick To Discriminate between Pharmacokinetics/Pharmacodynamics Models with Distinct Heterogeneous Subpopulations versus Homogenous Population with Adaptive Resistance

Journal article published in 2020 by A. Chauzy ORCID, H. Ih, M. Jacobs, S. Marchand ORCID, N. Grégoire, W. Couet ORCID, J. M. Buyck ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Experiments were conducted with polymyxin B and two Klebsiella pneumonia isogenic strains (the wild type, KP_WT, and its transconjugant carrying the mobile colistin resistance gene, KP_MCR-1) to demonstrate that conducting two consecutive time-kill experiments (sequential TK) represents a simple approach to discriminate between pharmacokinetics/pharmacodynamics models with two heterogeneous subpopulations or adaptive resistance.