The aim of this case study was to show how, with the use of software, is it possible to carry out a preventive screening of vehicular emissions. Moreover, thanks to this preliminary analysis, some areas that are potentially polluted can be identified in advance and suitable samplings on small-scale on them would help to verify the effectiveness of policies that can be adopted for the reduction of pollution. To this end, this paper reports a case study on vehicle traffic pollution in Calabria, a region in the south of Italy. We used the methodology called Corinair (Coordination Information AIR), developed by the EEA (European Environment Agency) and uses the software Copert4 (Computer Program to calculate Emission from Road Traffic). The total emissions per area were analyzed and the emissions for particular pollutants per unit area (km²) and per citizen were considered. The obsolete vehicles determined a substantial impact on the local atmospheric pollution. It was demonstrated how it is possible to substantially reduce the pollution of an area by adopting policies that encourage, for example, through tax concessions, the replacement of old cars of private citizens.