Published in
Royal Society of Chemistry, Chemical Science, 22(11), p. 5759-5765, 2020
DOI: 10.1039/d0sc01814g
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“CLipP”ing on lipids to generate antibacterial lipopeptides
Journal article published in 2020 by
Victor Yim 
,
Iman Kavianinia ,
Melanie K. Knottenbelt,
Scott A. Ferguson ,
Gregory M. Cook,
Simon Swift ,
Aparajita Chakraborty,
Jane R. Allison ,
Alan J. Cameron,
Paul W. R. Harris ,
Margaret A. Brimble
,
Iman Kavianinia ,
Melanie K. Knottenbelt,
Scott A. Ferguson ,
Gregory M. Cook,
Simon Swift ,
Aparajita Chakraborty,
Jane R. Allison ,
Alan J. Cameron,
Paul W. R. Harris ,
Margaret A. Brimble
This paper is made freely available by the publisher.
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Abstract
We herein report the synthesis and biological and computational evaluation of 12 linear analogues of the cyclic lipopeptide battacin, enabled by Cysteine Lipidation on a Peptide or Amino Acid (CLipPA) technology.