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American Association for the Advancement of Science, Science Advances, 21(6), 2020

DOI: 10.1126/sciadv.aaz4926

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All major cholesterol-dependent cytolysins use glycans as cellular receptors

Journal article published in 2020 by Lucy K. Shewell ORCID, Christopher J. Day ORCID, Freda E.-C. Jen ORCID, Thomas Haselhorst ORCID, John M. Atack ORCID, Josephine F. Reijneveld ORCID, Arun Everest-Dass ORCID, David B. A. James, Kristina M. Boguslawski ORCID, Stephan Brouwer ORCID, Christine M. Gillen ORCID, Zhenyao Luo, Bostjan Kobe ORCID, Victor Nizet ORCID, Mark von Itzstein ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Eight major CDCs use glycans as cellular receptors to potentiate cytotoxicity and bind glycans and cholesterol independently.