Abstract Rose is a plant of high nutritional requirement, susceptible to powdery mildew disease caused by fungus Oidium leucoconium, which causes leaf fall and losses in flower production. The objective of this study was to evaluate powdery mildew severity in rose cultivar ‘Grand Gala’ in response to organic fertilization and the application of alternative products to disease control. The first experiment was set in a factorial arrangement, with 5 alternative products: spraying with water as a control (PA), lime sulfur (CS), neem oil (ON), mixture of sodium bicarbonate and canola oil (BC) and coffee pyroligneous acid (APC) and 2 organic fertilizers: chicken manure (EA) and biofertilizer based on banana stalk (B). Disease severity was assessed at 0, 15, 30 and 45 days after the treatments. In the second experiment, asymptomatic leaves or with different powdery mildew severity levels were sprayed only once with the same alternative products mentioned above. Severity was assessed at 0, 7 and 14 days. The organic fertilizations did not influence the reduction in powdery mildew severity in rose. At 45 days, APC yielded a greater reduction in disease severity (81.6%), followed by treatments based on BC, ON and CS. Greater reduction in disease severity in experiment 2 occurred in the treatments of BC and CS, followed by APC. Therefore, it is possible to conclude that APC and the BC have the potential to control rose powdery mildew in an organic cultivation system.