American Physiological Society, American Journal of Physiology - Heart and Circulatory Physiology, 1(319), p. H66-H75, 2020
DOI: 10.1152/ajpheart.00733.2019
Full text: Unavailable
With aging, a reduction in the stiffness gradient between elastic and muscular arteries is thought to reduce wave reflection in conduit arteries, leading to increased pulsatile pressure transmission into the microvasculature. This assumes that wave reflection limits pressure transmission in arteries. However, using a computational model, we showed that wave reflection promotes pulsatile pressure transmission, although it does limit hydraulic energy transmission. Increased microvascular pulse pressure with aging is instead related to decreasing arterial compliance.