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American Physiological Society, American Journal of Physiology - Heart and Circulatory Physiology, 1(319), p. H66-H75, 2020

DOI: 10.1152/ajpheart.00733.2019

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Conduit arterial wave reflection promotes pressure transmission, but impedes hydraulic energy transmission, to the microvasculature

Journal article published in 2020 by Avinash Kondiboyina ORCID, Joseph J. Smolich ORCID, Michael M. H. Cheung, Berend E. Westerhof ORCID, Jonathan P. Mynard ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

With aging, a reduction in the stiffness gradient between elastic and muscular arteries is thought to reduce wave reflection in conduit arteries, leading to increased pulsatile pressure transmission into the microvasculature. This assumes that wave reflection limits pressure transmission in arteries. However, using a computational model, we showed that wave reflection promotes pulsatile pressure transmission, although it does limit hydraulic energy transmission. Increased microvascular pulse pressure with aging is instead related to decreasing arterial compliance.