AbstractFully coherent, soft X-ray attosecond pulses are now available through high-order harmonic generation (HHG); however, the output energy is insufficient for various applications, such as attosecond-scale soft X-ray nonlinear experiments, the seeding of soft X-ray free-electron lasers, attosecond-pump-attosecond-probe spectroscopies, and single-shot imaging. In this paper, we combine a newly developed TW class mid-infrared femtosecond laser and a loose focusing geometry for HHG. A soft X-ray harmonic beam up to the water window region is demonstrated, which is more than 100 times intense compared to previous works. We achieve a high conversion efficiency, low beam divergence and a significantly reduced medium gas pressure. As the first application, we demonstrate near edge X-ray absorption fine structure experiments with clear fine absorption spectra near the K- and L-edges observed. The robust energy scaling method on HHG opens the door for demonstrating single-shot absorption spectrum and live-cell imaging with a femtosecond time resolution.