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Royal Society of Chemistry, Chemical Science, 21(11), p. 5532-5536, 2020

DOI: 10.1039/d0sc00074d

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Modular bioengineered kinase sensorsviascaffold protein-mediated split-luciferase complementation

Journal article published in 2020 by Xiaolu Xu, Lenne J. M. Lemmens ORCID, Anniek den Hamer ORCID, Maarten Merkx ORCID, Christian Ottmann ORCID, Luc Brunsveld ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Phosphorylation is a key regulation event in cellular signaling. To sense the underlying kinase activity, we engineered modular and easy adaptable serine kinase sensors for the exemplary kinases PKA, PKB and CHK1.