Published in

Rockefeller University Press, Journal of Cell Biology, 7(219), 2020

DOI: 10.1083/jcb.202003031

Links

Tools

Export citation

Search in Google Scholar

Confounding factors from inducible systems for spatiotemporal gene expression regulation

Journal article published in 2020 by Rob C. I. Wüst ORCID, Riekelt H. Houtkooper ORCID, Johan Auwerx ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Green circle
Preprint: archiving allowed
Green circle
Postprint: archiving allowed
Green circle
Published version: archiving allowed
Data provided by SHERPA/RoMEO

Abstract

Spatiotemporally regulated targeted gene manipulation is a common way to study the effect of gene variants on phenotypic traits, but the Cre/loxP and Tet-On/Tet-Off systems can affect whole-organism physiology and function due to off-target effects. We highlight some of these adverse effects, including whole-body endocrinology and disturbances in the gut microbiome and in mitochondrial and metabolic function.