High-bentonite mud (HBM) is a water-based drilling fluid characterized by its remarkable improvement in cutting removal and hole cleaning efficiency. Periodic monitoring of the rheological properties of HBM is mandatory for optimizing the drilling operation. The objective of this study is to develop new sets of correlations using artificial neural network (ANN) to predict the rheological parameters of HBM while drilling using the frequent measurements, every 15 to 20 min, of mud density (MD) and Marsh funnel viscosity (FV). The ANN models were developed using 200 field data points. The dataset was divided into 70:30 ratios for training and testing the ANN models respectively. The optimized ANN models showed a significant match between the predicted and the measured rheological properties with a high correlation coefficient (R) higher than 0.90 and a maximum average absolute percentage error (AAPE) of 6%. New empirical correlations were extracted from the ANN models to estimate plastic viscosity (PV), yield point (YP), and apparent viscosity (AV) directly without running the models for easier and practical application. The results obtained from AV empirical correlation outperformed the previously published correlations in terms of R and AAPE.