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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 5(64), 2020

DOI: 10.1128/aac.02300-19

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Evaluation of Dose-Fractionated Polymyxin B on Acute Kidney Injury Using a Translational In Vivo Rat Model

Journal article published in 2020 by Jiajun Liu ORCID, Gwendolyn M. Pais ORCID, Sean N. Avedissian ORCID, Annette Gilchrist ORCID, Andrew Lee, Nathaniel J. Rhodes ORCID, Alan R. Hauser, Marc H. Scheetz ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We investigated dose-fractionated polymyxin B (PB) on acute kidney injury (AKI). PB at 12 mg of drug/kg of body weight per day (once, twice, and thrice daily) was administered in rats over 72 h. The thrice-daily group demonstrated the highest KIM-1 increase ( P = 0.018) versus that of the controls ( P = 0.99) and histopathological damage ( P = 0.013). A three-compartment model best described the data (bias, 0.