Noble metallic nanoparticles, silver (AgNPs) and gold (AuNPs) mainly, exhibit good antimicrobial, antibacterial, and antifungal properties and, therefore, have a significant contribution to the constant growing field of nanomedicine. They can be synthesized using both conventional or unconventional methods and, in the last decades especially, the unconventional routes that use plants as raw vegetal materials are studied with proven results. On the other hand, macrocyclic derivatives such as phthalocyanines (Pcs) have photoactive properties and numerous applications. The conjugation between silver and gold nanoparticles with phthalocyanine derivatives considerably increases both the photochemical activity of Pcs as well as the stability of noble metallic nanoparticles. This paper describes recent research in the field of green-synthesized AgNPs and AuNPs from different plants with important pharmacological applications in two different temperature conditions: at room temperature, for 12 h, and at 50 °C for 30 min. AgNPs and AuNPs then react with tetracarboxamido-zinc phthalocyanine ZnPc(CONH2)4 and octacarboxamido–zinc phthalocyanine ZnPc(CONH2)8 to obtain two hybrid nanoaggregates, confirmed by spectroscopic analyses and by determining their antioxidant and antimicrobial activity.