Dissemin is shutting down on January 1st, 2025

Published in

Japanese Society for Intravascular Neosurgery, Interventional Neuroradiology, 4(26), p. 494-500, 2020

DOI: 10.1177/1591019920925708

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The Cascade device – In vitro tests to assess coil protrusion into the parent vessel

Journal article published in 2020 by P. Bhogal ORCID, K. Wong, Hld Makalanda
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Preprint: policy unknown
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Postprint: policy unknown
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Published version: policy unknown
Data provided by SHERPA/RoMEO

Abstract

Background Balloon and stent-assisted coiling of aneurysms have increased the number of aneurysms available for endovascular treatment. Newer devices that allow flow within the parent vessel but coverage at the neck have recently entered the market. The Cascade is a new non-occlusive fully retrievable neck-bridging support device that has been designed to provide temporary support during coil embolisation of intracranial aneurysms. Methods Using a silicone aneurysm model three different aneurysms were catheterised with the coiling microcatheter placed in three different positions within each aneurysm – at the neck, centrally, and looped within the aneurysm. Multiple different coils were then deployed within each aneurysm with the Cascade device deployed across the neck to provide protection. In total 480 attempted coilings were performed. Aneurysm flow was used to calculate the change in intra-aneurysmal flow with the Cascade device deployed across the neck of the aneurysm. Results We did not observe a single episode of coil protrusion through the Cascade mesh nor did we observe any coil protrusion into the parent vessel when the Cascade was deployed across the neck. There was an average flow velocity reduction of 23% with the Cascade device deployed across the neck of the aneurysm. Conclusion The Cascade device offers robust protection of the aneurysmal neck and parent vessel as well as inducing significant intra-aneurysmal flow velocity reduction.