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BMJ Publishing Group, Gut, 3(46), p. 308-309, 2000

DOI: 10.1136/gut.46.3.308

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Bile acids are physiological ligands for a nuclear receptor

Journal article published in 2000 by J. R. F. Walters ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7 alpha-hydroxylase, which is the rate-limiting enzyme in bile acid synthesis, and activated the gene encoding intestinal bile acid-binding protein, which is a candidate bile acid transporter. These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport.