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MDPI, Marine Drugs, 12(11), p. 387-398, 2013

DOI: 10.3390/md11020387

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Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris

Journal article published in 2013 by Jesús Martín, Thiciana da S. Sousa, Mercedes de la Cruz, Thiciana da S. Sousa, Gloria Crespo, Sara Palomo, Ignacio González ORCID, José R. Tormo ORCID, Matthew Anderson, Russell T. Hill, Francisca Vicente, Olga Genilloud ORCID, Fernando Reyes ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A new thiazolyl peptide, kocurin (1), was isolated from culture broths of a marine-derived Kocuria palustris. Its structural elucidation was accomplished using a combination of spectroscopic and chemical methods, including HRMS, extensive 1D and 2D NMR analysis, MS/MS fragmentation, and chemical degradation and Marfey’s analysis of the resulting amino acid residues. The structure herein reported corrects that previously assigned to PM181104 (3). Kocurin displayed activity against methicillin-resistant Staphylococcus aureus (MRSA), with MIC values in the submicromolar range.