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Royal Society of Chemistry, RSC Advances, 28(10), p. 16727-16731, 2020

DOI: 10.1039/d0ra03291c

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Induction of ADCC by a folic acid–mAb conjugate prepared by tryptophan-selective reaction toward folate-receptor-positive cancer cells

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

mAb–folic acid conjugates were prepared by a tryptophan-selective reaction using an organic radical under ambient conditions, which showed significant induction ability of antibody-dependent cellular cytotoxicity.