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Elsevier, Biophysical Journal, 1(76), p. 409-413, 1999

DOI: 10.1016/s0006-3495(99)77207-3

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Estimating the Persistence Length of a Worm-Like Chain Molecule from Force-Extension Measurements

Journal article published in 1999 by C. Bouchiat, M. D. Wang, J.-F. Allemand ORCID, T. R. Strick, S. M. Block, V. Croquette
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We describe a simple computation of the worm-like chain model and obtain the corresponding force-versus-extension curve. We propose an improvement to the Marko and Siggia interpolation formula of Bustamante et al (Science 1994, 265:1599-1600) that is useful for fitting experimental data. We apply it to the experimental elasticity curve of single DNA molecules. Finally, we present a tool to study the agreement between the worm-like chain model and experiments.