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Revista de Chimie, 3(71), p. 425-432, 2001

DOI: 10.37358/rc.20.3.8016

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Matrix Gla Protein in Meningiomas: An Immunohistochemical Study

Journal article published in 2001 by Simona Roxana Gheorghe, Ligia Gabriela Tataranu, Anica Dricu, Ciprian Nicolae Silaghi ORCID, Cees Vermeer, Alexandra Marioara Craciun
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

Calcified meningiomas have a slower growth rate and a better outcome than non-calcified meningiomas. Matrix Gla Protein (MGP) acts as an inhibitor of soft tissue calcification. Depending on its carboxylation status MGP may occur in two conformations: uncarboxylated (ucMGP) or carboxylated (cMGP). Low levels of serum ucMGP have been described to be a sign of tissue calcification. In calcified tumoral tissue samples we identified both ucMGP (r = 0.957, p[0.001) and cMGP (r = 1, p[0.001), while non-calcified tumors were negative for both MGP conformation deposits. The concentration of serum t-ucMGP in patients with calcified and non-calcified meningiomas were not significantly different (3499�1388 vs. 3882�2558).