National Academy of Sciences, Proceedings of the National Academy of Sciences, 8(117), p. 4158-4168, 2020
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Significance Our studies establish a connection between two isolated observations that 1) statins, taken by millions to lower cholesterol, have antitumor activity and 2) Ras-induced macropinocytosis is important in tumorigenesis. We discover that by depleting GGPP required for pseudopod extension and macropinocytosis, statins selectively kill cells with oncogenic defects by limiting nutrient uptake.