Published in
American Physiological Society, American Journal of Physiology - Gastrointestinal and Liver Physiology, 4(318), p. G803-G815, 2020
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Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization
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Cristina Øie,
Mohammed Benkheil,
Wouter Dheedene,
Stefan Vinckier,
Giulia Coppiello,
Xabier López Aranguren,
Manu Beerens,
Joris Jaekers,
Baki Topal,
Catherine Verfaillie,
Bård Smedsrød,
Aernout Luttun
Full text: Unavailable
Abstract
Liver sinusoidal endothelial cells (LSECs) are the first liver cells to encounter waste macromolecules, pathogens, and toxins in the blood and are highly specialized. Although some transcription factors are known to play a role in LSEC specialization, information about the specialized LSEC signature and its transcriptional determinants remains incomplete. Here, we show that C-MAF, GATA4, and MEIS2 are important transcriptional regulators of the unique LSEC signature and that they affect the interaction of LSECs with viruses.