Abstract Background Aortopulmonary window is a congenital heart disease requiring a surgical approach to achieve a complete correction. Case summary We report on a case of a young female symptomatic adult patient with a significant aortopulmonary window. The patients refused surgical approach and since the defect was far enough from the pulmonary and aortic valve a percutaneous approach was proposed. The large aortopulmonary window was closed effectively with an Amplatzer Muscular Septal Occluder device (Abbott, Plymouth, MN, USA). At 1-year follow-up, the device was in a good position with no residual shunt. Discussion Transcatheter closure of an aortopulmonary window is an effective and safe procedure in specific anatomic defects.