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Royal Society of Chemistry, Chemical Science, 13(11), p. 3511-3515, 2020

DOI: 10.1039/c9sc05903b

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Unravelling the effect of the E545K mutation on PI3Kα kinase

Journal article published in 2020 by Ioannis Galdadas ORCID, Francesco Luigi Gervasio, Zoe Cournia ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The mechanism by which the cancer-causing E545K mutation may lead to PI3Kα activation is described in atomic-level detail.