The worldwide trend towards headache (HA) chronization is an important medical and social problem due to frequent psychological and social maladaptation of patients. Chronic HAs reduce quality of life and patients ability to work. The trend towards headache chronization is largely associated with acceleration of the pace of life, constant social and informational tension, leading to emotional disturbances, such as depression, anxiety, and asthenia. Single medical interventions do not seem to have a lasting effect. Thus, such patients require long-term comprehensive rehabilitation with regard to the type and characteristic features of HA, as well as triggers and comorbid condition. Rehabilitation should include adequate long-term drug therapy aimed at preventing exacerbations of HA. Additional approaches may include botulinum neurotoxin injections, physiotherapy (biofeedback, transcranial magnetic stimulation, transcranial electrical stimulation), psychotherapy, comorbid conditions diagnosis and treatment, lifestyle intervention.