Interleukin 10 (IL-10) is an antiinflammatory cytokine, but also promotes B cell responses and plays a pathogenic role in systemic lupus erythematosus (SLE). CD4 ⁺ CCR6 ⁺ IL-7R ⁺ T cells from human tonsils produced IL-10 following stimulation by naïve B cells, which promoted B cell immunoglobulin G (IgG) production. These tonsillar CCR6 ⁺ B helper T cells were phenotypically distinct from follicular helper T (T _FH ) cells and lacked BCL6 expression. In peripheral blood, a CCR6 ⁺ T cell population with similar characteristics was identified, which lacked Th17- and T _FH -associated gene signatures and differentiation-associated surface markers. CD4 ⁺ CCR6 ⁺ T cells expressing IL-10, but not IL-17, were also detectable in the spleens of cytokine reporter mice. They provided help for IgG production in vivo, and expanded systemically in pristane-induced lupus-like disease. In SLE patients, CD4 ⁺ CCR6 ⁺ IL-7R ⁺ T cells were associated with the presence of pathogenic anti-dsDNA (double-stranded DNA) antibodies, and provided spontaneous help for autoantibody production ex vivo. Strikingly, IL-10–producing CCR6 ⁺ T cells were highly abundant in lymph nodes of SLE patients, and colocalized with B cells at the margins of follicles. In conclusion, we identified a previously uncharacterized population of extrafollicular B helper T cells, which produced IL-10 and could play a prominent pathogenic role in SLE.