Aim: The receptor for advanced glycation end products (RAGE) is a viable target for early Alzheimer’s disease (AD) diagnosis using positron emission tomography (PET) as RAGE overexpression precedes Aβ plaque formation. The development of a carbon-11 analog of FPS-ZM1 (N-benzyl-4-chloro-N-cyclohexylbenzamide, [¹¹C]FPS-ZM1), possessing nanomolar affinity for RAGE, may enable the imaging of RAGE for early AD detection. Methodology & results: Herein we report an optimized [¹¹C]CO₂-to-[¹¹C]CO chemical conversion for the synthesis of [¹¹C]FPS-ZM1 and in vitro brain autoradiography. The [¹¹C]CO₂-to-[¹¹C]CO conversion via ¹¹C-silanecarboxylate derivatives was achieved with a 57% yield within 30 s from end of [¹¹C]CO₂ delivery. [¹¹C]FPS-ZM1 was obtained with a decay-corrected isolated radiochemical yield of 9.5%. Conclusion: [¹¹C]FPS-ZM1 distribution in brain tissues of wild-type versus transgenic AD model mice showed no statistically significant difference and high nondisplaceable binding.