Published in
American Association for the Advancement of Science, Science Advances, 12(6), 2020
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Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death
Journal article published in 2020 by
S. Busker 
,
W. Qian,
M. Haraldsson,
B. Espinosa,
L. Johansson,
S. Attarha ,
I. Kolosenko,
J. Liu ,
M. Dagnell ,
D. Grandér,
E. S. J. Arnér ,
K. Pokrovskaja Tamm ,
B. D. G. Page
,
W. Qian,
M. Haraldsson,
B. Espinosa,
L. Johansson,
S. Attarha ,
I. Kolosenko,
J. Liu ,
M. Dagnell ,
D. Grandér,
E. S. J. Arnér ,
K. Pokrovskaja Tamm ,
B. D. G. Page
This paper is made freely available by the publisher.
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Abstract
Redox regulation of STAT3 is targeted by direct inhibition of TrxR1, illuminating a promising link for therapeutic development.