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American Association for the Advancement of Science, Science, 6462(366), p. 250-254, 2019

DOI: 10.1126/science.aax1522

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Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula

Journal article published in 2019 by Y. Otsu ORCID, E. Darcq ORCID, K. Pietrajtis ORCID, F. Mátyás ORCID, E. Schwartz ORCID, T. Bessaih, S. Abi Gerges ORCID, C. V. Rousseau, T. Grand ORCID, S. Dieudonné ORCID, P. Paoletti ORCID, L. Acsády ORCID, C. Agulhon ORCID, B. L. Kieffer ORCID, M. A. Diana ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

An inhibitor causes neuronal excitation Glycine is thought to be primarily an inhibitory neurotransmitter. However, it also acts as a coagonist on excitatory N -methyl-D-aspartate (NMDA) receptors. Otsu et al. examined the function of the NMDA receptor subunit combination GluN1/GluN3A in the medial habenula (MHb) of adult mice. This NMDA receptor subunit combination in MHb neurons is activated by glycine released from astrocytes. Activation of GluN1/GluN3A NMDA receptors causes depolarization and increased spiking of MHb neurons. Reducing GluN3A receptor subunit levels in the MHb blocks conditioned place aversion. Science , this issue p. 250