Published in
American Association for the Advancement of Science, Science Translational Medicine, 519(11), 2019
DOI: 10.1126/scitranslmed.aaw4626
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Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis
Journal article published in 2019 by
Kofi A. Mensah 
,
Jeff W. Chen ,
Jean-Nicolas Schickel,
Isabelle Isnardi,
Natsuko Yamakawa ,
Andrea Vega-Loza,
Jennifer H. Anolik,
Richard A. Gatti,
Erwin W. Gelfand,
Ruth R. Montgomery ,
Mark C. Horowitz,
Joe E. Craft ,
Eric Meffre
,
Jeff W. Chen ,
Jean-Nicolas Schickel,
Isabelle Isnardi,
Natsuko Yamakawa ,
Andrea Vega-Loza,
Jennifer H. Anolik,
Richard A. Gatti,
Erwin W. Gelfand,
Ruth R. Montgomery ,
Mark C. Horowitz,
Joe E. Craft ,
Eric Meffre
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Abstract
Defective ATM activation skews the B cell repertoire and increases RANKL production, promoting joint erosion in patients with rheumatoid arthritis.