Published in
American Association for the Advancement of Science, Science Signaling, 623(13), 2020
DOI: 10.1126/scisignal.aaw8130
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PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling
Journal article published in 2020 by
Shen Yang 
,
Mattias N. D. Svensson ,
Nathaniel H. O. Harder ,
Wan-Chen Hsieh,
Eugenio Santelli ,
William B. Kiosses ,
James J. Moresco ,
John R. Yates ,
Charles C. King,
Lin Liu,
Stephanie M. Stanford,
Nunzio Bottini
,
Mattias N. D. Svensson ,
Nathaniel H. O. Harder ,
Wan-Chen Hsieh,
Eugenio Santelli ,
William B. Kiosses ,
James J. Moresco ,
John R. Yates ,
Charles C. King,
Lin Liu,
Stephanie M. Stanford,
Nunzio Bottini
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Abstract
Phosphorylation of PTPN22 at Ser 751 balances phosphatase degradation and plasma membrane recruitment.