The method of stage vacant place and subsequent filling has been used in an iron mine in Anhui province, but the effect of underground filling with local cement dose not meet the requirements. Therefore, the cementitious material was developed which suitable for the actual situation of the mine. In this paper, the basic properties, fluidity of filling slurry and strength of filling body between local cement and cementitious materials are compared and studied. The experimental results show that the diffusion of filling slurry with new cementitious material is higher 37.93% than the filling slurry with local cement, and the compressive strength of filling body is higher 75.82% than the filling body with local cement. The testing indexes of the new cementitious material are better than the local cement. Therefore, the new cementitious material for mining can be well adapted to the cemented filling of tailings in this mine. Through the comparative experimental study in this paper, the data support and theoretical basis of performance evaluation and industrial application are provided for mine filling cementitious materials.