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National Institute of Environmental Health Sciences (NIEHS), Environmental Health Perspectives, Suppl 1(115), p. 106-114, 2007

DOI: 10.1289/ehp.9358

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Low-Level Exposure to Multiple Chemicals: Reason for Human Health Concerns?

Journal article published in 2007 by Andreas Kortenkamp, Michael Faust, Martin Scholze, Thomas Backhaus ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The widely held view that mixtures of dissimilarly acting chemicals are "safe" at levels below NOAELs is not supported by empirical evidence. We show that this view is also based on the erroneous assumption that NOAELs can be equated with zero-effect levels. Thus, on the basis of published evidence, it is difficult to rule out the possibility of mixture effects from low-dose multiple exposures.