Published in
Georg Thieme Verlag, Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 11(2010), p. 1631-1634
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Synthesis of a Racemic Nicotine-Lobeline Hybrid
Journal article published in 2010 by
Tsiresy Ranaivondrambola,
Fx X. Felpin 
,
Wilfried Hatton,
Monique Mathe-Allainmat,
Michel Evain,
Jacques Lebreton
,
Wilfried Hatton,
Monique Mathe-Allainmat,
Michel Evain,
Jacques Lebreton
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Abstract
The first synthesis of a racemic nicotine-lobeline hybrid is described based on a diastereoselective allylation and an RCM reaction as key steps. This synthetic route paves the way to the preparation of original potential ligands of nAChRs.