Soybean (Glicine max L.) is one of the most important crops from the economic standpoint for Brazil and due to the favorable climate for the development of fungal diseases, requires special needs. The fungal diseases with the greatest economic impact on Brazilian culture are Asian rust, caused by the fungus Phakopsora pachyrhizi and Anthracnose, caused by Colletotrichum truncatum. Together, without proper control, they can be devastating. Fungicides represent a high cost to producers, however, necessary for productivity losses do not decrease production. In this way, obtaining a combination of fungicides that provides results for the control of the diseases, from the beginning of the infestation period, with a satisfactory cost benefit is of the utmost importance to Brazilian producers. The objective of this study was to evaluate the combination of six commercial fungicides (APROACH PRIMA®, SPHERE MAX®, FOX®, FUSÃO®, ELATUSTM and ORKESTRA) and sequential applications in the control of anthracnosis and asian rust at the soybean cultivar “Monsoy 5947 IPRO”; besides establishing the best cost benefit for the application of these fungicides. The results show that all evaluated treatments presented statistically significant result, and suggest the use of Orkestra®/Aproach Prima®/Sphere Max® fungicides in sequential applications for the control of Asian rust and anthracnose in the region of Assis Chateaubriant, Paraná, Brazil.