Published in
National Academy of Sciences, Proceedings of the National Academy of Sciences, 45(116), p. 22721-22729, 2019
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Polymerase III transcription is necessary for T cell priming by dendritic cells
Journal article published in 2019 by
Marisa Reverendo,
Rafael J. Argüello 
,
Christine Polte,
Jan Valečka,
Voahirana Camosseto,
Nathalie Auphan-Anezin ,
Zoya Ignatova,
Evelina Gatti,
Philippe Pierre
,
Christine Polte,
Jan Valečka,
Voahirana Camosseto,
Nathalie Auphan-Anezin ,
Zoya Ignatova,
Evelina Gatti,
Philippe Pierre
This paper is made freely available by the publisher.
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Abstract
Significance RNA polymerase III-dependent transcription and increased tRNA expression are necessary for MAMP-stimulated DCs to stimulate naïve T cells. Augmented Pol III-dependent transcription is as essential as the switch to glycolysis and other energetic metabolism variations that are now considered as hallmarks of immune cell activation and are all necessary to increase protein synthesis in these cells.