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American Society for Microbiology, Applied and Environmental Microbiology, 15(76), p. 5300-5304, 2010

DOI: 10.1128/aem.00851-10

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Inhibition of Salmonella Host Cell Invasion by Dimethyl Sulfide

Journal article published in 2010 by L. Caetano M. Antunes, Michelle M. C. Buckner, Sigrid D. Auweter, Rosana B. R. Ferreira ORCID, Petra Lolić, B. Brett Finlay
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We show that dimethyl sulfoxide (DMSO) inhibits Salmonella hilA expression and that this inhibition is stronger under anaerobiosis. Because DMSO can be reduced to dimethyl sulfide (DMS) during anaerobic growth, we hypothesized that DMS was responsible for hilA inhibition. Indeed, DMS strongly inhibited the expression of hilA and multiple Salmonella pathogenicity island 1 (SPI-1)-associated genes as well as the invasion of cultured epithelial cells. Because DMSO and DMS are widespread in nature, we hypothesize that this phenomenon may contribute to environmental sensing by Salmonella .