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American Society for Microbiology, Journal of Bacteriology, 15(192), p. 4063-4066, 2010

DOI: 10.1128/jb.00383-10

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The MerR/NmlR Family Transcription Factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production

Journal article published in 2010 by Adam J. Potter, Stephen P. Kidd ORCID, Alastair G. McEwan, James C. Paton
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The NmlR sp transcription factor of Streptococcus pneumoniae is shown to induce adhC (alcohol dehydrogenase) expression in the presence of both formaldehyde and methylglyoxal. nmlR sp and adhC mutant strains display altered and opposite aerobic growth phenotypes. The nmlR sp strain exhibits increased resistance to high oxygen tension, attributable to decreased H 2 O 2 production, which correlated with downregulation of carbamoyl phosphate synthase ( carB ). This indicates a possible role for AdhC in aldehyde metabolism and a broader role for NmlR sp in the regulation of carbon metabolism.