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Elsevier, Journal of Neuroimmunology, 1-2(187), p. 55-60, 2007

DOI: 10.1016/j.jneuroim.2007.04.011

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TNFα-Induced Sickness Behavior in Mice with Functional 55 kD TNF Receptors is Blocked by Central IGF-I

Journal article published in 2007 by Karine Palin, Rose-Marie Bluthé, Robert H. McCusker, Françoise Moos, Robert Dantzer ORCID, Keith W. Kelley
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This paper is available in a repository.

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Abstract

A variety of pathogenic insults cause synthesis of tumor necrosis factor (TNF)alpha in the brain, resulting in sickness behavior. Here we used TNF-receptor (TNF-R)2-deficient and wild-type mice to demonstrate that the reduction in social exploration of a novel juvenile, the increase in immobility and the loss of body weight caused by central TNFalpha (i.c.v., 50 ng/mouse) are blocked by central pre-treatment with the multifunctional peptide, insulin-like growth factor (IGF-I; i.c.v., 300 ng/mouse). These results establish that sickness behavior induced by central TNFalpha via the TNF-R1 (p55) is directly opposed by IGF-I in the brain.