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American Association for the Advancement of Science, Science Advances, 8(6), 2020

DOI: 10.1126/sciadv.aay3178

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Intrinsic disorder controls two functionally distinct dimers of the master transcription factor PU.1

Journal article published in 2020 by Suela Xhani ORCID, Sangchoon Lee ORCID, Hye Mi Kim, Siming Wang ORCID, Shingo Esaki, Van L. T. Ha, Mahtab Khanezarrin, Giselle L. Fernandez, Amanda V. Albrecht, James M. Aramini, Markus W. Germann ORCID, Gregory M. K. Poon ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Distinct dimeric forms of PU.1 mutually antagonize to control the transcriptionally active dose via a disordered PEST domain.