Published in
American Society for Microbiology, Infection and Immunity, 3(88), 2020
DOI: 10.1128/iai.00534-19
Links
Tools
Biogenesis of the Spacious Coxiella-Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3
Journal article published in 2019 by
Bhavna Padmanabhan 
,
Laura F. Fielden,
Abderrahman Hachani ,
Patrice Newton,
David R. Thomas,
Hyun-Jung Cho,
Chen Ai Khoo,
Diana Stojanovski,
Craig R. Roy ,
Nichollas E. Scott ,
Hayley J. Newton
,
Laura F. Fielden,
Abderrahman Hachani ,
Patrice Newton,
David R. Thomas,
Hyun-Jung Cho,
Chen Ai Khoo,
Diana Stojanovski,
Craig R. Roy ,
Nichollas E. Scott ,
Hayley J. Newton
This paper is made freely available by the publisher.
Full text: Download
Data provided by 
Abstract
Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates inside the lysosome-derived Coxiella -containing vacuole (CCV). To establish this unique niche, C. burnetii requires the Dot/Icm type IV secretion system (T4SS) to translocate a cohort of effector proteins into the host cell, which modulate multiple cellular processes.