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Nature Research, Nature Communications, 1(11), 2020

DOI: 10.1038/s41467-020-16256-y

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A human monoclonal antibody blocking SARS-CoV-2 infection

Journal article published in 2020 by Chunyan Wang, Wentao Li ORCID, Dubravka Drabek ORCID, Nisreen M. A. Okba ORCID, Rien van Haperen, Albert D. M. E. Osterhaus, Frank J. M. van Kuppeveld, Bart L. Haagmans ORCID, Frank Grosveld, Berend-Jan Bosch ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractThe emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.