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Royal Society of Chemistry, Chemical Science, 7(11), p. 1892-1904, 2020

DOI: 10.1039/c9sc04284a

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Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells

Journal article published in 2020 by Isabelle R. Taylor, Victoria A. Assimon, Szu Yu Kuo, Silvia Rinaldi, Xiaokai Li, Zapporah T. Young, Giulia Morra, Keith Green, Daniel Nguyen, Hao Shao ORCID, Sylvie Garneau-Tsodikova ORCID, Giorgio Colombo ORCID, Jason E. Gestwicki ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Dominant negative mutants are useful tools in chemical biology, but they do not mimic the action of allosteric inhibitors. We show that properly-placed tryptophan residues can sometimes be superior for this purpose.