We study the evolution of non-linear structure as a function of scale in samples from the 2dF Galaxy Redshift Survey, constituting over 221 000 galaxies at a median redshift of z=0.11. The two flux-limited galaxy samples, located near the southern galactic pole and the galactic equator, are smoothed with Gaussian filters of width ranging from 5 to 8 Mpc/h to produce a continuous galaxy density field. The topological genus statistic is used to measure the relative abundance of overdense clusters to void regions at each scale; these results are compared to the predictions of analytic theory, in the form of the genus statistic for i) the linear regime case of a Gaussian random field; and ii) a first-order perturbative expansion of the weakly non-linear evolved field. The measurements demonstrate a statistically significant detection of an asymmetry in the genus statistic between regions corresponding to low- and high-density volumes of the universe. We attribute the asymmetry to the non-linear effects of gravitational evolution and biased galaxy formation, and demonstrate that these effects evolve as a function of scale. We find that neither analytic prescription satisfactorily reproduces the measurements, though the weakly non-linear theory yields substantially better results in some cases, and we discuss the potential explanations for this result. ; Comment: 13 pages, matching proof to be published in MNRAS; new version adds reference and corrects figure 6