The purpose of this study was to analyze the characteristics of arterial hypertension clinical course in patients with sleep disorders for optimization of preventive and curative interventions algorithms, blood pressure control, cardiovascular complications prevention, improvement of patients’ life quality. Materials and Methods: We examined 89 patients with arterial hypertension aged from 30 to 70 years. The arterial hypertension diagnosis was based on ESC Clinical Practice Guidelines – ESC/ESH Arterial Hypertension (Management of) (2018). We analyzed the clinical, instrumental and laboratory status of patients with arterial hypertension. All data was evaluated with STATGRAPHICS 5.1, Microsoft Office Excel, Statistica 8.0. Results: the patients with arterial hypertension have expressed dissomnic and psychosomatic disorders which have significant negative influence on the arterial hypertension clinical course and the disease prognosis. Low urine melatonin level is associated with increased blood pressure, blood pressure variability, sleep disorders, psychosomatic disorders, and low life quality of patients with arterial hypertension. Prescription of melatonin in the patients with arterial hypertension with sleep disorders is reasonable to correct dissomnic and psychosomatic disorders, clinical symptoms load of arterial hypertension, improvement of disease prognosis and life quality of patients with arterial hypertension. Keywords: arterial hypertension, sleep disorders, psychosomatic disorders, melatonin, quality of life.