Dissemin is shutting down on January 1st, 2025

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American Association for the Advancement of Science, Science Advances, 16(6), 2020

DOI: 10.1126/sciadv.aaz7602

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Sperm DNA damage causes genomic instability in early embryonic development

Journal article published in 2020 by Sjors Middelkamp ORCID, Helena T. A. van Tol, Diana C. J. Spierings ORCID, Sander Boymans ORCID, Victor Guryev ORCID, Bernard A. J. Roelen ORCID, Peter M. Lansdorp, Edwin Cuppen ORCID, Ewart W. Kuijk ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Sperm cells with damaged DNA cause mitotic errors in the fertilized embryo, leading to a diverse spectrum of genomic abnormalities.