There is a high incidence of the comorbid non-psychotic anxiety disorders in oncology patients. The choice of psychopharmacological treatment for this group of patients is a difficult task needing consideration of the complex of clinical psychosocial factors, peculiarities of the tumor process course, illness prognosis and pharmacological interactions. The article proposes the anxiolytic therapy algorithm, describes the psychopharmacological treatment in the framework od the complex healthcare services and oncology illnesses rehabilitation.