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National Academy of Sciences, Proceedings of the National Academy of Sciences, 51(116), p. 26020-26028, 2019

DOI: 10.1073/pnas.1916867116

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Polarized PtdIns(4,5)P <sub>2</sub> distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility

Journal article published in 2019 by Takafumi Kawai, Haruhiko Miyata, Hiroki Nakanishi, Souhei Sakata, Shin Morioka, Junko Sasaki, Masahiko Watanabe ORCID, Kenji Sakimura ORCID, Toyoshi Fujimoto ORCID, Takehiko Sasaki, Masahito Ikawa ORCID, Yasushi Okamura ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance Voltage-sensing phosphatase (VSP) is a unique protein that consists of both the voltage-sensor domain and phosphoinositide phosphatase domain. In contrast with intensive studies on its molecular mechanisms, its physiological role has not been clear. Here, we report that VSP plays critical roles in mouse sperm motility. We found that VSP generates a polarized distribution of PtdIns(4,5)P 2 in the sperm flagellum, which is critical for regulation of ion channel activity and calcium influx in sperm function. This provides a mode of regulation of ion channel activity by biased distribution of PtdIns(4,5)P 2 .