Published in
American Society of Hematology, Blood Advances, 5(3), p. 711-717, 2019
DOI: 10.1182/bloodadvances.2018028720
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Pharmacologic control of CAR-T cell function using dasatinib
Journal article published in 2019 by
Evan W. Weber,
Rachel C. Lynn,
Elena Sotillo,
John Lattin 
,
Peng Xu,
Crystal L. Mackall
,
Peng Xu,
Crystal L. Mackall
This paper is made freely available by the publisher.
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Abstract
Key Points Dasatinib potently and reversibly suppresses CAR-T cell cytotoxicity, cytokine secretion, and proliferation. Dasatinib could be repurposed as a safety switch to mitigate CAR-mediated toxicity in patients.