Published in
American Society of Hematology, Blood Advances, 11(3), p. 1695-1700, 2019
DOI: 10.1182/bloodadvances.2019000043
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Enhanced labile plasma iron in hematopoietic stem cell transplanted patients promotes Aspergillus outgrowth
Journal article published in 2019 by
Verena Petzer 
,
Martin Wermke,
Piotr Tymoszuk ,
Dominik Wolf,
Markus Seifert,
Rıdvan Ovaçin,
Sylvia Berger,
Dorothea Orth-Höller,
Lorin Loacker,
Günter Weiss ,
Hubertus Haas ,
Uwe Platzbecker ,
Igor Theurl
,
Martin Wermke,
Piotr Tymoszuk ,
Dominik Wolf,
Markus Seifert,
Rıdvan Ovaçin,
Sylvia Berger,
Dorothea Orth-Höller,
Lorin Loacker,
Günter Weiss ,
Hubertus Haas ,
Uwe Platzbecker ,
Igor Theurl
This paper is made freely available by the publisher.
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Abstract
Key Points Serum-enhanced labile plasma iron in patients undergoing allogeneic HSCT is critical for Aspergillus fumigatus growth in vitro. Transferrin iron in serum is inaccessible for A fumigatus, and uptake of iron in the form of eLPI involves fungal siderophores.