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American Society of Hematology, Blood Advances, 12(3), p. 1788-1794, 2019

DOI: 10.1182/bloodadvances.2018025247

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CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK+ lymphoma after transplantation

Journal article published in 2019 by Soumya Sundara Rajan, Lingxiao Li, Mercedes F. Kweh, Kranthi Kunkalla, Amit Dipak Amin ORCID, Nitin K. Agarwal, Francisco Vega ORCID, Jonathan H. Schatz ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points CRISPR/Cas9 genomic editing of wild-type hematopoietic stem cells generates Npm1-Alk, leading to ALK+ large-cell lymphomas in recipients. CD30+ postthymic T-cell lymphomas are polyclonal but transplantable to secondary recipients with long latency.