Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease

Yearsley, Karen; Zambar, Veena; Zeissig, Sebastian; Walker, Gareth J.; Jones, Samuel E.; Kanegasundaram, Suren; Karban, Amir; Katsanos, Konstantinos H.; Kiparissi, Fevronia; Voskuil, Michiel D.; Kirkham, Sian; Lal, Simon; Langlands, Sarah; Lawrance, Ian C.; Lees, Charlie W.; Lev-Tzion, Raffi; Levison, Scott; Lewis, Stephen J.; Li, Andy; Limdi, Jimmy; Lin, Simeng; Lobo, Alan; Lockett, Melanie; Harrison, James W.; Loehry, Juliette; MacDonald, Chris; MacFaul, George; Mahmood, Tariq; Mann, Steve; Heap, Graham A.; Mawdsley, Joel; Mazhar, Zia; McGovern, Jane F.; McNair, Alistair; Modi, Anita; Andersen, Vibeke; Monahan, Kevin; Moran, Alex; Morris, Mary-Anne; Anderson, Carl A.; Mortimore, Marianne; Mowat, Craig; Muhammed, Rafeeq; Ananthakrishnan, Ashwin N.; Murray, Charles D. R.; Olivier, Hanlie; Barrett, Jeffrey C.; Orchard, Timothy R.; Panter, Simon; Patel, Vinod; Beaugerie, Laurent; Phillips, Rosemary; Prasad, Neeraj; Bewshea, Claire M.; Preston, Cathryn; Radford-Smith, Graham; Cole, Andy T.; Rajasekhar, Praveen; Koskela, Jukka; Roy, Dipak; Cummings, Fraser R.; Saich, Rebecca; Lindsay, James O.; Satsangi, Jack; Daly, Mark J.; Schreiber, Stefan; Mansfield, John C.; Sen, Sandip; Ellul, Pierre; Shah, Neil; McGovern, Dermot; Shenderay, Richard; Fedorak, Richard N.; Shenoy, Acuth; Parkes, Miles; Shutt, James; Silverberg, Mark; Festen, Eleonora A. M.; Pollok, Richard C. G.; Simmons, Alison; Simmons, Jonathan; Florin, Timothy H.; Ramakrishnan, Subramaniam; Singh, Salil; Smith, Malcolm; Gaya, Daniel R.; Smith, Mark; Rampton, David S.; Smith, Melissa; Snook, Jonathon A.; Halfvarson, Jonas; Rivas, Manuel A.; Sonwalker, Sunil; Stevens, Christine R.; Hart, Ailsa L.; Sturniolo, Giacomo; Russell, Richard K.; Subramanian, Sreedhar; Heerasing, Neel M.; Thomas, Amanda; Schultz, Michael; Tighe, Mark; Hendy, Peter; Torrente, Franco; Sebastian, Shaji; Tremelling, Mark; Irving, Peter M.; Tsianos, Epameinondas; Seksik, Philippe; Vani, Deven; Walsh, Alissa; Watermeyer, Gillian; Singh, Abhey; Watts, David; Watts, Gill; So, Kenji; Weaver, Sean; Wesley, Emma; Willmott, Anne; Sokol, Harry; Subramaniam, Kavitha; Holden, Arthur L.; Andrews, Jane; Auth, Marcus; Todd, Anthony; Babu, Sathish; Bampton, Peter; Banim, Paul; Barnes, Theresa; Basude, Dharam; Beckly, John; Bell, Andy; Bell, Sally; Weersma, Rinse K.; Bhandari, Pradeep; Bloom, Stuart; Border, Dave; Bredin, Francesca; Xavier, Ramnik; Brookes, Matthew J.; Brown, Matthew; Calvert, Chris; Ward, Rebecca; Campbell, David; Chanchlani, Neil; Chaudhary, Basant; Chaudhary, Rakesh; Weedon, Michael N.; Chung-Faye, Guy; Colleypriest, Ben; Connor, Susan; Annese, Vito; Cooney, Rachel; Cooper, Sheldon; Kennedy, Nicholas A.; Creed, Tom J.; Croft, Nick; Cullen, Sue; D'Amato, Mauro; Dalal, Helen; Daneshmend, Tawfique K.; Das, Debasish; Delaney, Michael; Desilva, Shanika; Dhar, Anjan; Dharmasiri, Suranga; Goodhand, James R.; Direkze, Natalie; Dunckley, Paul; Elphick, David; Everett, Simon M.; Feeney, Mark; Fell, John; Foley, Stephen; Ahmad, Tariq; Franke, Andre; Gavin, Daniel; Gee, Ian; Ghosh, Deb; Goldsmith, Christopher; Gorard, David; Gordon, John N.; Gore, Steve; Green, John; Grimes, David; Hamill, Grace; Harbord, Marcus; Hart, James; Hawkey, Chris; Iqbal, Tariq; Ireland, Alan; Johnson, Matt; Ibd, Pharmacogenetics Study Group; Jones, Colin

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American Medical Association, Journal of the American Medical Association, 8(321), p. 773, 2019

DOI: 10.1001/jama.2019.0709

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Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease

Journal article published in 2019 by Karen Yearsley, Veena Zambar, Sebastian Zeissig, Gareth J. Walker, Samuel E. Jones, Suren Kanegasundaram, Amir Karban, Konstantinos H. Katsanos, Fevronia Kiparissi, Michiel D. Voskuil, Sian Kirkham, Simon Lal, Sarah Langlands, Ian C. Lawrance, Charlie W. Lees and other authors.

This paper is made freely available by the publisher.

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Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease